Fertility planning
Optimizing reproductive health ahead of conception attempts — applies to both partners.
Preconception cofactor + specialist-guided adjuncts (both partners) · 2 phases · guided multi-peptide program with decision criteria and add-to-stack handoff.
What changes during this transition
Kisspeptin is the most directly relevant peptide for fertility — it's the upstream signal that drives endogenous GnRH → LH/FSH → gonadal steroid production. Clinical use is investigational in induced ovulation cycles and hypogonadism. Beyond kisspeptin, the relevant work is general health optimization: thyroid, metabolic, and inflammation profiles all affect fertility. For users who have suppressed their HPG axis (TRT, AAS), restart protocols typically use hCG (not a peptide) and clomid (not a peptide) — kisspeptin is the experimental peptide alternative. Female users with low ovarian reserve (AMH-tracked) have fewer peptide options; lifestyle and supplementation play larger roles.
Important caveat
Trying to conceive should involve a reproductive medicine specialist, not a peptide stack. Many peptides are contraindicated during pregnancy and breastfeeding — confirm the user is not currently pregnant or planning imminent conception before recommending any peptide.
Peptides editorially relevant to fertility planning
4 peptides from the library — each evidence-tiered honestly.
- KisspeptinTier 2
KISS1R agonist (hypothalamic neuropeptide)
Sits at the very top of the reproductive axis — triggers the cascade that produces sex hormones. Strong clinical-research evidence for hypogonadism and IVF use; off-label 'natural T' community use in healthy men runs ahead of the data.
- CJC-1295Tier 3
GHRH analog
Long-acting GHRH analog often paired with a GHRP. Strong PK data in humans; outcome data is limited.
- IpamorelinTier 3
GHRP / ghrelin mimetic
Selective GH-releasing peptide with minimal cortisol or prolactin elevation in early studies. Human outcome evidence is limited.
- B12 (Methylcobalamin)Tier 1
Vitamin (methylcobalamin)
Vitamin B12 in the methyl form. Solid evidence for treating documented deficiency and pernicious anemia. The wellness-clinic 'energy injection' market for non-deficient adults has no clinical-trial support.
Want this list to grow? The library is editorial — if there’s a peptide you think belongs on this page with documented or mechanistically-clear evidence, send us a note with the citation and we’ll review it under the same evidence-tier discipline as every other entry.