What it does
Glutathione is the body's most abundant intracellular antioxidant — a short tripeptide of glutamate, cysteine, and glycine — central to liver detoxification pathways, redox balance, and the neutralization of reactive cellular byproducts. Its inclusion in this 'peptide companion' library follows the same logic as NAD+: it is technically a peptide (a tripeptide), is heavily marketed alongside peptide regimens, and most users encounter it through IV-clinic protocols rather than as a primary intervention. The strongest clinical evidence is indirect — N-acetylcysteine, the rate-limiting precursor for the body to make its own glutathione, is the standard antidote for paracetamol (acetaminophen) overdose. The IV-clinic marketing for skin lightening, brain-fog 'detox,' and general anti-aging runs well past the supporting evidence, particularly given persistent unresolved questions about IV and oral glutathione bioavailability and its rapid plasma clearance.
Used for
Dose
- Starting
- 200,000 mcg · 1–3× per week (clinic IV)
- Common
- 1,100,000 mcg · 1–3× per week (clinic IV)
- Upper
- 2,000,000 mcg · 1–3× per week (clinic IV)
- When
- MorningAntioxidant load handles best in the morning with the day's redox demand ahead. IV-clinic protocols frequently pair with vitamin C in the same morning slot.
- Site
- intravenous (clinic infusion)
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⚠ Caution
- Asthma (rare reports of bronchospasm with IV glutathione, particularly in sulfite-sensitive patients)
- Active sulfite hypersensitivity
- Pregnancy and breastfeeding (limited human safety data outside the NAC paracetamol-overdose context)
- Cysteine metabolism disorders
- Known hypersensitivity to glutathione or formulation excipients
Your stack
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