What it does
Tesamorelin / Ipamorelin pairs a stabilized GHRH analog with a selective GHRP in a fixed-ratio vial. Tesamorelin is the only FDA-approved peptide indication specifically for visceral fat reduction (Egrifta, HIV-associated lipodystrophy) and brings strong human VAT-reduction evidence; Ipamorelin adds a clean ghrelin-pathway GH pulse without cortisol/prolactin elevation. The combination amplifies the GH pulse magnitude beyond Tesamorelin alone.
Dose
- Dose
- 1,000 mcg · 5 days/week (30 units of a 10/5 mg vial)
- When
- Bedtime1–2 hours before bed, fasted, aligns the GHRH-driven GH pulse with the natural overnight slow-wave-sleep GH window — same logic as the individual components.
- How long
- 6 months on / 2 months off
- Site
- subcutaneous, before bed, fasted 2+ h
- Food
- fasted
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⚠ Caution
- Active malignancy (relative; raised IGF-1 is theoretically permissive of tumor growth)
- Uncontrolled diabetes / acute glucose dysregulation (GH is counter-regulatory; tesamorelin can transiently elevate fasting glucose)
- Pituitary surgery, radiation, or trauma — confirm pituitary axis with provider first
- Severe heart failure; severe respiratory failure or critical illness
- Pregnancy and breastfeeding
- Competitive athletes — GH secretagogues are WADA-banned
- Hypersensitivity to mannitol/excipients or to ipamorelin
Will it work for me?
Establish a baseline (2–3 readings over 1–2 weeks before starting), then track at consistent intervals.
Blood markers
- Tier 1 — Human RCTIGF-1↑· by 8 weeks; keep within age-adjusted range — do not chase supraphysiologicPrimary objective marker; the Ipamorelin layer amplifies the pulse but does not change the marker set.
- Tier 1 — Human RCTTriglycerides↓· 12–26 weeksImproves alongside VAT reduction in the Tesamorelin trials.
Functional & psychometric
- Tier 3 — Animal / in vitroWaist circumference + visceral adipose tissue (DEXA)↓· 12–26 weeksVAT via DEXA was the primary FDA-trial endpoint for Tesamorelin; tracked functionally here.
Your stack
Track this peptide in your protocol — dose, schedule, vials on hand, refill projection. Stays in your browser; no account needed.
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