8-OHdG (urinary, oxidative DNA damage)

Reference ranges

No reference ranges recorded for this biomarker yet.

Peptide relevance

8-hydroxy-2'-deoxyguanosine — urinary marker of oxidative DNA damage. NO HARMONIZED REFERENCE RANGE — values depend on assay method (ELISA, HPLC-MS) and normalization (per mg creatinine to control for urine concentration). Most labs report typical ranges 1-15 ng/mg creatinine. Useful as a longitudinal marker of oxidative stress reduction interventions: glutathione precursors (N-acetyl-cysteine, glycine), mitochondrial peptides (SS-31 / elamipretine, MOTS-c), CoQ10, exercise. Higher = more oxidative damage; lower = better antioxidant defense. KEY CAVEAT: ELISA can over-report due to cross-reactivity; HPLC-MS is more accurate but more expensive. First-morning void recommended. Track trend within same assay/lab; cross-lab comparisons unreliable.

Peptides that influence this marker

Documented to affect this marker. Click through for the full evidence-tiered profile.

• Glutathione
  Tripeptide antioxidant (companion supplement)

  Direct redox buffer — lowers oxidative DNA damage in trials

• MOTS-c
  Mitochondrial-derived peptide

  Mitochondrial-derived peptide with antioxidant signaling effects

• SS-31 (Elamipretide)
  Mitochondrial-targeted peptide

  Mitochondrial-targeted antioxidant; theoretical 8-OHdG reduction