Burnout / chronic fatigue / asthenia
Persistent low energy, motivation collapse, post-stress exhaustion — not explained by anemia or thyroid dysfunction.
Mitochondrial + cofactor stack · 3 phases · guided multi-peptide program with decision criteria and add-to-stack handoff.
Pineal-axis + sleep-architecture peptides · 2 phases · guided multi-peptide program with decision criteria and add-to-stack handoff.
What changes during this transition
The Russian-research tradition has a specific class for this — actoprotectors (bromantane is the prototypical one) and adaptogenic anxiolytics (selank). Both target the dopaminergic + serotonergic + HPA-axis systems implicated in chronic stress states. Evidence is Tier 3 in Russian clinical literature, Tier 4 in Western. Cerebrolysin is the most evidenced for fatigue post-stroke or post-traumatic states. Mitochondrial-targeted peptides (SS-31, MOTS-c) are theorized to address the underlying cellular-energy deficit in some fatigue states; human data is limited.
Important caveat
Rule out medical causes first: anemia (full iron panel + B12 + folate + ferritin), thyroid dysfunction (TSH + free T4 + free T3 + reverse T3 + antibodies), cortisol dysregulation (AM cortisol + DHEA-S), sleep apnea, depression. Don't use stimulating peptides to mask correctable underlying issues.
Peptides editorially relevant to burnout / chronic fatigue / asthenia
7 peptides from the library — each evidence-tiered honestly.
- BromantaneTier 3
Synthetic adamantane derivative (anti-asthenic / actoprotector)
Russian-developed anti-asthenic. Indirect dopaminergic effect via tyrosine hydroxylase upregulation. Tier 3 in Russian clinical literature; no Western replication. WADA-banned for athletes. Not technically a peptide — included for community completeness.
- SelankTier 3
Synthetic tuftsin analog (heptapeptide)
Russian-developed anxiolytic/nootropic peptide. Most clinical data is in Russian and methodologically thin by Western standards. Tier 3. Routes include intranasal — a natural pair with Juno's nasal-spray prep guide.
- SemaxTier 3
Synthetic ACTH(4-10) analog (heptapeptide)
Russian-developed nootropic and neuroprotective peptide. Registered there as a prescription product for stroke; most of the clinical evidence is Russian-language and not independently replicated outside that body of work.
- CerebrolysinTier 2
Porcine-derived neuropeptide mixture
Multi-peptide cocktail from porcine brain, manufactured by EVER Pharma. Approved in Europe / Asia / Russia for ischemic stroke, dementia, and TBI. NOT US-approved. Tier 1/2 abroad in approved indications; Tier 3 for off-label use.
- SS-31 (Elamipretide)Tier 2
Mitochondrial-targeted peptide
Mitochondrial-targeted peptide. FDA-approved for Barth syndrome (2024); explored in other mitochondrial conditions and as a longevity compound.
- MOTS-cTier 3
Mitochondrial-derived peptide
Mitochondrial-encoded peptide with strong rodent data on insulin sensitivity, endurance, and metabolic health.
- DihexaTier 3
HGF / c-Met agonist (cognitive)
Animal-only peptide aimed at restoring brain connections, with replicated cognitive-recovery signals in rodent models of Alzheimer's disease. No human trials.
Want this list to grow? The library is editorial — if there’s a peptide you think belongs on this page with documented or mechanistically-clear evidence, send us a note with the citation and we’ll review it under the same evidence-tier discipline as every other entry.